Congreve,, Miles : rechercher sur Z-Library

Le plus grand référentiel d'articles scientifiques au monde. 70,000,000+ d'articles gratuitement.

Don't use scam websites

Livres
Articles (77)
Les plus populaires
Liste
- Liste
- Tableau

1

Crystal structure of the GLP-1 receptor bound to a peptide agonist

Jazayeri, Ali, Rappas, Mathieu, Brown, Alastair J. H., Kean, James, Errey, James C., Robertson, Nathan J., Fiez-Vandal, Cédric, Andrews, Stephen P., Congreve, Miles, Bortolato, Andrea, Mason, Jonathan

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 6.41 MB

english, 2017

2

A ‘Rule of Three’ for fragment-based lead discovery?

Miles Congreve, Robin Carr, Chris Murray, Harren Jhoti

Journal:

Drug Discovery Today

Année:

2003

Langue:

english

Fichier:

PDF, 24 KB

english, 2003

3

Identification of a novel allosteric GLP–1R antagonist HTL26119 using structure- based drug design

O'Brien, Alistair, Andrews, Steve, Baig, Asma H., Bortolato, Andrea, J. H. Brown, Alastair, Brown, Giles A., Brown, Sue H., Christopher, John A., Congreve, Miles, Cooke, Robert M., De Graaf, Chris, Er

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2019

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2019

4

Impact of GPCR Structures on Drug Discovery

Congreve, Miles, de Graaf, Chris, Swain, Nigel A., Tate, Christopher G.

Journal:

Année:

2020

Fichier:

PDF, 2.58 MB

2020

5

The impact of GPCR structures on pharmacology and structure-based drug design

Miles Congreve, Fiona Marshall

Journal:

British Journal of Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 390 KB

english, 2010

6

Fragment-based lead discovery

Rees, David C., Congreve,, Miles, Murray, Christopher W., Carr, Robin

Journal:

Nature Reviews Drug Discovery

Année:

2004

Langue:

english

Fichier:

PDF, 283 KB

english, 2004

7

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

Andrew S. Doré, Nathan Robertson, James C. Errey, Irene Ng, Kaspar Hollenstein, Ben Tehan, Edward Hurrell, Kirstie Bennett, Miles Congreve, Francesca Magnani, Christopher G. Tate, Malcolm Weir, Fiona

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2011

8

Keynote review: Structural biology and drug discovery

Miles Congreve, Christopher W. Murray, Tom L. Blundell

Journal:

Drug Discovery Today

Année:

2005

Langue:

english

Fichier:

PDF, 238 KB

english, 2005

9

Progress in Structure Based Drug Design for G Protein-Coupled Receptors

Congreve, Miles, Langmead, Christopher J., Mason, Jonathan S., Marshall, Fiona H.

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 10.73 MB

english, 2011

10

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Murray, Christopher W., Carr, Maria G., Callaghan, Owen, Chessari, Gianni, Congreve, Miles, Cowan, Suzanna, Coyle, Joseph E., Downham, Robert, Figueroa, Eva, Frederickson, Martyn

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.37 MB

english, 2010

11

Recent Developments in Fragment-Based Drug Discovery

Congreve, Miles, Chessari, Gianni, Tisi, Dominic, Woodhead, Andrew J.

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 3.59 MB

english, 2008

12

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Woodhead, Andrew J., Angove, Hayley, Carr, Maria G., Chessari, Gianni, Congreve, Miles, Coyle, Joseph E., Cosme, Jose, Graham, Brent, Day, Philip J., Downham, Robert, Fazal, Lynsey, Feltell, Ruth, Fig

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 4.98 MB

english, 2010

13

Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs

Congreve, Miles, Oswald, Christine, Marshall, Fiona H.

Journal:

Trends in Pharmacological Sciences

Année:

2017

Langue:

english

Fichier:

PDF, 2.07 MB

english, 2017

14

Perspective in Medicinal Chemistry: Structure-Based Drug Design

Congreve, Miles, Andrews, Steve

Journal:

Current Topics in Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 636 KB

english, 2016

15

Recent Developments in Therapeutic Peptides for the Glucagon-like Peptide 1 and 2 Receptors

Suzuki, Rie, Brown, Giles, Christopher, John A., Scully, Conor, Congreve, Miles

Journal:

Journal of Medicinal Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 2.32 MB

english, 2019

16

Analysis of Solid-Phase Reactions: Product Identification and Quantification by Use of UV-Chromophore-Containing Dual-Linker Analytical Constructs

Geoff M. Williams, Robin A. E. Carr, Miles S. Congreve, Corinne Kay, Stephen C. McKeown, Peter J. Murray, Jan J. Scicinski, Stephen P. Watson

Journal:

Angewandte Chemie

Année:

2000

Langue:

english

Fichier:

PDF, 104 KB

english, 2000

17

Analytical Construct Resins for Analysis of Solid-Phase Chemistry

Miles S. Congreve, Steven V. Ley, Jan J. Scicinski

Journal:

Chemistry - A European Journal

Année:

2002

Langue:

english

Fichier:

PDF, 250 KB

english, 2002

18

Analysis of Solid-Phase Reactions: Product Identification and Quantification by Use of UV-Chromophore-Containing Dual-Linker Analytical Constructs

Geoff M. Williams, Robin A. E. Carr, Miles S. Congreve, Corinne Kay, Stephen C. McKeown, Peter J. Murray, Jan J. Scicinski, Stephen P. Watson

Journal:

Angewandte Chemie International Edition

Année:

2000

Langue:

english

Fichier:

PDF, 191 KB

english, 2000

19

Detection of Ligands from a Dynamic Combinatorial Library by X-ray Crystallography

Miles S. Congreve, Deborah J. Davis, Lindsay Devine, Cesare Granata, Marc O′Reilly, Paul G. Wyatt, Harren Jhoti

Journal:

Angewandte Chemie International Edition

Année:

2003

Langue:

english

Fichier:

PDF, 230 KB

english, 2003

20

Synthesis of (+)-Obtusenyne

S. Y. Frankie Mak, Neil R. Curtis, Andrew N. Payne, Miles S. Congreve, Andrew J. Wildsmith, Craig L. Francis, John E. Davies, Sofia I. Pascu, Jonathan W. Burton, Andrew B. Holmes

Journal:

Chemistry - A European Journal

Année:

2008

Langue:

english

Fichier:

PDF, 644 KB

english, 2008

21

ChemInform Abstract: A Rapid Approach for the Optimization of Polymer-Supported Reagents in Synthesis.

Craig Jamieson, Miles S. Congreve, David F. Emiabata-Smith, Steven V. Ley

Journal:

Année:

2001

Fichier:

PDF, 29 KB

2001

22

ChemInform Abstract: Analytical Construct Resins for Analysis of Solid-Phase Chemistry

Miles S. Congreve, Steven V. Ley, Jan J. Scicinski

Journal:

Année:

2002

Fichier:

PDF, 25 KB

2002

23

Versatile solid-phase synthesis of secondary amines from alcohols. Development of an N-Boc-(o-nitrobenzene)sulfonamide linker

Miles S. Congreve, Corinne Kay, Jan J. Scicinski, Steven V. Ley, Geoffrey Williams, Peter J. Murray, Stephen C. McKeown, Stephen P. Watson

Journal:

Tetrahedron Letters

Année:

2003

Langue:

english

Fichier:

PDF, 256 KB

english, 2003

24

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

van Montfort, Rob L. M., Congreve, Miles, Tisi, Dominic, Carr, Robin, Jhoti, Harren

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 341 KB

english, 2003

25

Deal watch: Valuation benefits of structure-enabled drug discovery

Borshell, Nigel, Congreve, Miles

Journal:

Nature Reviews Drug Discovery

Année:

2011

Langue:

english

Fichier:

PDF, 158 KB

english, 2011

26

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors

Cho, Young Shin, Angove, Hayley, Brain, Christopher, Chen, Christine Hiu-Tung, Cheng, Hong, Cheng, Robert, Chopra, Rajiv, Chung, Kristy, Congreve, Miles, Dagostin, Claudio, Davis, Deborah J., Feltell,

Journal:

ACS Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 3.61 MB

english, 2012

27

High-throughput analytical techniques for reaction optimization

Miles S Congreve, Craig Jamieson

Journal:

Drug Discovery Today

Année:

2002

Langue:

english

Fichier:

PDF, 75 KB

english, 2002

28

High-throughput analytical techniques for reaction optimization

Miles S Congreve, Craig Jamieson

Journal:

Drug Discovery Today

Année:

2002

Langue:

english

Fichier:

PDF, 75 KB

english, 2002

29

Fragment-based lead discovery: leads by design

Robin A.E. Carr, Miles Congreve, Christopher W. Murray, David C. Rees

Journal:

Drug Discovery Today

Année:

2005

Langue:

english

Fichier:

PDF, 134 KB

english, 2005

30

Application of ReactArray Robotics and Design of Experiments Techniques in Optimisation of Supported Reagent Chemistry

Jamieson, Craig, Congreve, Miles S., Emiabata-Smith, David F., Ley, Steven V., Scicinski, Jan J.

Journal:

Organic Process Research & Development

Année:

2002

Langue:

english

Fichier:

PDF, 105 KB

english, 2002

31

Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator†

Chessari, Gianni, Congreve, Miles, Cowan, Suzanna R., Matthews, Julia E., McMenamin, Rachel, Smith, Donna-Michelle, Vinković, Mladen, Wallis, Nicola G., Callaghan, Owen, Frederickson, Martyn

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 660 KB

english, 2008

32

New insights from structural biology into the druggability of G protein-coupled receptors

Jonathan S. Mason, Andrea Bortolato, Miles Congreve, Fiona H. Marshall

Journal:

Trends in Pharmacological Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 3.45 MB

english, 2012

33

Identification of Novel Adenosine A 2A Receptor Antagonists by Virtual Screening

Langmead, Christopher J., Andrews, Stephen P., Congreve, Miles, Errey, James C., Hurrell, Edward, Marshall, Fiona H., Mason, Jonathan S., Richardson, Christine M., Robertson, Nathan, Zhukov, Andrei, W

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 277 KB

english, 2012

34

Biophysical Mapping of the Adenosine A 2A Receptor

Zhukov, Andrei, Andrews, Stephen P., Errey, James C., Robertson, Nathan, Tehan, Benjamin, Mason, Jonathan S., Marshall, Fiona H., Weir, Malcolm, Congreve, Miles

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2011

35

Discovery of 1,2,4-Triazine Derivatives as Adenosine A 2A Antagonists using Structure Based Drug Design

Congreve, Miles, Andrews, Stephen P., Doré, Andrew S., Hollenstein, Kaspar, Hurrell, Edward, Langmead, Christopher J., Mason, Jonathan S., Ng, Irene W., Tehan, Benjamin, Zhukov, Andrei, Weir, Malcolm,

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 2.19 MB

english, 2012

36

Detection of Ligands from a Dynamic Combinatorial Library by X-ray Crystallography

Miles S. Congreve, Deborah J. Davis, Lindsay Devine, Cesare Granata, Marc O′Reilly, Paul G. Wyatt, Harren Jhoti

Journal:

Angewandte Chemie

Année:

2003

Langue:

english

Fichier:

PDF, 229 KB

english, 2003

37

Solid-Phase Development of a 1-Hydroxybenzotriazole Linker for Heterocycle Synthesis Using Analytical Constructs

Scicinski, Jan J., Congreve, Miles S., Jamieson, Craig, Ley, Steven V., Newman, Emma S., Vinader, Victoria M., Carr, Robin A. E.

Journal:

Journal of Combinatorial Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 127 KB

english, 2001

38

Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors †

Howard, Nigel, Abell, Chris, Blakemore, Wendy, Chessari, Gianni, Congreve, Miles, Howard, Steven, Jhoti, Harren, Murray, Christopher W., Seavers, Lisa C. A., van Montfort, Rob L. M.

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 291 KB

english, 2006

39

Development of an Indole Safety-Catch Linker Using Analytical Constructs

Scicinski, Jan J., Congreve, Miles S., Ley, Steven V.

Journal:

Journal of Combinatorial Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 168 KB

english, 2004

40

[Methods in Enzymology] Fragment-Based Drug Design - Tools, Practical Approaches, and Examples Volume 493 || Fragment Screening of Stabilized G-Protein-Coupled Receptors Using Biophysical Methods

Congreve, Miles

Année:

2011

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2011

41

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency §

Edwards, Philip D., Albert, Jeffrey S., Sylvester, Mark, Aharony, David, Andisik, Donald, Callaghan, Owen, Campbell, James B., Carr, Robin A., Chessari, Gianni, Congreve, Miles, Frederickson, Martyn,

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 359 KB

english, 2007

42

Development and Application of a Carbonyl- 13 C-Enriched Backbone Amide Linker for Solid-Phase Reaction Monitoring

Jamieson, Craig, Congreve, Miles S., Hewitt, Peter R., Scicinski, Jan J., Ley, Steven V.

Journal:

Journal of Combinatorial Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 46 KB

english, 2001

43

[Advances in Pharmacology] Pharmacology of G Protein Coupled Receptors Volume 62 || The Use of GPCR Structures in Drug Design

Congreve, Miles

Année:

2011

Langue:

english

Fichier:

PDF, 770 KB

english, 2011

44

Ascidiatrienolide A is a 10-membered lactone

Congreve, Miles S., Holmes, Andrew B., Hughes, Andrew B., Looney, Mark G.

Journal:

Journal of the American Chemical Society

Année:

1993

Langue:

english

Fichier:

PDF, 265 KB

english, 1993

45

Treatment and prevention of various therapeutic conditions using OX receptor antagonistic activity (WO2012081692)

Christopher, John A, Congreve, Miles S

Journal:

Expert Opinion on Therapeutic Patents

Année:

2013

Langue:

english

Fichier:

PDF, 457 KB

english, 2013

46

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 42 Volume 42 || Chapter 28 Fragment-Based Lead Discovery

Congreve, Miles

Année:

2007

Langue:

english

Fichier:

PDF, 167 KB

english, 2007

47

Structure-based drug design of chromone antagonists of the adenosine A2A receptor

Andrews, Stephen P., Mason, Jonathan S., Hurrell, Edward, Congreve, Miles

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 460 KB

english, 2014

48

Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase §

Congreve, Miles, Aharony, David, Albert, Jeffrey, Callaghan, Owen, Campbell, James, Carr, Robin A. E., Chessari, Gianni, Cowan, Suzanna, Edwards, Philip D., Frederickson, Martyn, McMenamin, Rachel, Mu

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 269 KB

english, 2007

49

Encyclopedia of Reagents for Organic Synthesis || 2-Ethyl-7-hydroxybenzisoxazolium Tetrafluoroborate

Congreve, Miles S.

Année:

2001

Langue:

english

Fichier:

PDF, 44 KB

english, 2001

50

Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

Gill, Adrian L., Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J., Carr, Maria G., Woodhead, Andrew J., Walker, Margaret T., Congreve, Miles S., Devine, Lindsay A., Tisi, Dominic, O'Reilly, Ma

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 686 KB

english, 2005